Many women over 40 are on hormone replacement therapy. Sometimes doctors prescribe oral hormones, sometimes sublingual hormones, and sometimes topical, or transdermal, hormones. The only one you need to worry about with your breeding animals are the transdermal hormones. Transdermal hormone preparations are made specifically to penetrate the skin and elevate blood levels of hormones. These hormone preparations are very good at penetrating skin: not just yours, but any skin they come in contact with. That means your family members and your animals are all at risk for absorbing these hormones, which can cause adverse effects.